AI Article Synopsis
- Glaucoma is a leading cause of irreversible blindness globally, primarily due to neurodegeneration.
- Research suggests that caloric restriction may help slow down the progression of neurodegenerative diseases, including those affecting the retina.
- The review emphasizes how caloric restriction influences autophagy, a process that may play a critical role in the survival of retinal ganglion cells (RGCs) during glaucoma.
Article Abstract
Glaucoma is the most common neurodegenerative cause of irreversible blindness worldwide. Restricted caloric regimens are an attractive approach for delaying the progression of neurodegenerative diseases. Here we review the current literature on the effects of caloric restriction on retinal neurons, under physiological and pathological conditions. We focused on autophagy as one of the mechanisms modulated by restricted caloric regimens and involved in the death of retinal ganglion cells (RGCs) over the course of glaucoma.
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| http://dx.doi.org/10.1016/bs.pbr.2020.07.005 | DOI Listing |
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