The regulation of the gene-regenerating family member 1 alpha (REG Iα) played important roles in cancer cell biology. However, the correlation between its gene product serum REG Iα and cancer has not been evaluated. In this observational study, 130 hospitalized patients from the department of internal medicine in Zhongda Hospital Southeast University were included and assigned to cancer or noncancer groups. History, clinical, and laboratory data were obtained. Serum REG Iα levels and alanine aminotransferase were found significantly higher in patients with cancer (P < .001 and P < .05 respectively). Logistic regression analysis indicated that REG Iα was an independent risk factor for cancer (P < .001). The area under the curve of REG Iα was 0.764 and the optimal cut-off point of REG Iα was 46.97 ng/mL. Besides, the cancer patients with metastasis had significantly higher serum REG Iα levels than those in nonmetastasis cancer group (P < .05). In conclusion, serum REG Iα was significantly elevated in patients with cancer, and it might be a potential biomarker in predicting cancer occurrence and development.
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http://dx.doi.org/10.1097/MD.0000000000022281 | DOI Listing |
Biomedicines
March 2024
Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Lancet Reg Health West Pac
December 2023
Global Centre for Preventative Health and Nutrition, Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, Australia.
Bioresour Technol
October 2023
Universidade de Vigo, Departamento de Enxeñaría Química, Facultade de Ciencias, 32004 Ourense, Spain; Instituto de Agroecoloxía e Alimentación (IAA). Universidade de Vigo - Campus Auga, 32004 Ourense, España.
This study describes the valorization of avocado seed (AS) within a green biorefinery concept using microwave-assisted autohydrolysis. After the treatment at temperatures of 150-230 °C for 5 min, the resulting solid and liquor were characterized. The temperature of 220 °C led to the simultaneous optimal values of antioxidant phenolics/flavonoids (42.
View Article and Find Full Text PDFMicroorganisms
December 2022
Institute of Horticulture, Lithuanian Research Centre for Agriculture and Forestry, Kaunas Str. 30, 54333 Babtai, Kaunas reg., Lithuania.
Brown rot caused by spp. fungi causes substantial losses in stone and pome fruit production. Reports suggest that up to 90% of the harvest could be lost.
View Article and Find Full Text PDFInt Urol Nephrol
March 2022
Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói-RJ, Brazil.
Purpose: Regular physical exercise may result in many benefits to patients with chronic kidney disease (CKD) on hemodialysis (HD), including gut microbiota modulation and solute removal. The study aimed to evaluate the effects of two programs of intradialytic exercises on uremic toxins plasma levels in HD patients.
Methods: In experiment 1, twenty HD patients [12 men, 44.
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