AI Article Synopsis
- Treating diseases during pregnancy is tricky because some medicines can harm the baby through the placenta, which usually protects the fetus.
- Scientists are looking at nanoparticles, which are tiny particles, to safely deliver medicine by controlling how it interacts with the placenta.
- The Review talks about using these nanoparticles to help treat problems in mothers or babies while keeping the unborn safe, and discusses the future of this technology.
Article Abstract
A major challenge to treating diseases during pregnancy is that small molecule therapeutics are transported through the placenta and incur toxicities to the developing fetus. The placenta is responsible for providing nutrients, removing waste, and protecting the fetus from toxic substances. Thus, the placenta acts as a biological barrier between the mother and fetus that can be exploited for drug delivery. Nanoparticle technologies provide the opportunity for safe drug delivery during pregnancy by controlling how therapeutics interact with the placenta. In this Review, we present nanoparticle drug delivery technologies specifically designed to exploit the placenta as a biological barrier to treat maternal, placental, or fetal diseases exclusively, while minimizing off-target toxicities. Further, we discuss opportunities, challenges, and future directions for implementing drug delivery technologies during pregnancy.
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| http://dx.doi.org/10.1016/j.addr.2020.09.006 | DOI Listing |
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