AI Article Synopsis
- Circular RNAs (circRNAs) are a new type of noncoding RNA that have been found to have significant biological roles, particularly in cancer development and progression.
- In a study focusing on gastric cancer, researchers identified a specific circRNA called circRIMS that enhances cancer cell metastasis by interacting with certain miRNAs (hsa-miR-148a-5p and hsa-miR-218-5p).
- CircRIMS shows potential as an early biomarker for predicting tumor invasion in gastric cancer, which could improve clinical diagnosis and treatment strategies.
Article Abstract
Circular RNAs (circRNAs), a new category of noncoding RNA, have emerged in recent years as novel biomolecules with important biological functions. Increasing evidence and reports have revealed that circRNAs play an important role in human carcinogenesis and tumor progression. Gastric cancer (GC) is one of the most prevalent life-threatening malignancies worldwide, and in the present study, a novel circRNA molecule (circRIMS) was shown to be associated GC metastasis using next-generation sequencing. CircRIMS remarkably promoted GC cell metastasis in vitro, functioning as a sponge for hsa-miR-148a-5p and hsa-miR-218-5p. In addition, the results of rescue experiments showed that hsa-miR-148a-5p and hsa-miR-218-5p mimics could reverse the tumor-promoting roles of circRIMS in GC. Thus, circRIMS has potential as an early biomarker for use in predicting invasive metastasis in GC and to guide clinical diagnosis and treatment for precision medicine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495717 | PMC |
| http://dx.doi.org/10.1021/acsomega.0c02991 | DOI Listing |
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