Background There has been an increasing incidence of drug abuse patients presenting with rhabdomyolysis after prolonged immobilization. Our study was to assess etiology and management challenges with patients presenting with gluteal compartment syndrome after drug abuse. Methodology We did a retrospective analysis of five patients who presented with gluteal compartment syndrome secondary to drug abuse over one year. Results We had a 100% association with rhabdomyolysis and acute renal injury necessitating hemodialysis. There was a frequent association with the involvement of additional compartments like thigh and leg. Conclusion Patients with drug overdose can present with unusual compartment syndrome involvement like the gluteal compartment. Compartment syndrome is a surgical emergency and needs multidisciplinary involvement.
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http://dx.doi.org/10.7759/cureus.9847 | DOI Listing |
Brain Spine
December 2024
Department of Neurosurgery, Neuroscience Center, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
Research Question: to describe and investigate the case of an 11-year-old boy with the concomitant pneumocephalus, subcutaneous- and orbitopalpebral emphysema after the removal of a giant meningioma. Furthermore, our aim is to discuss the findings and the pathophysiology in relation to cases found in literature.
Material And Methods: We performed a search in PubMed, Cochrane, MEDLINE and Google Scholar by the usage of the words orbital or periorbital, combined with emphysema and neurosurgery.
This analysis assessed the relationship between the plasma concentrations of loperamide and its N-desmethyl loperamide meta- bolite (M1) and the potential QT interval prolongation at therapeutic and supratherapeutic doses. The exposure-response analysis was performed using the data from healthy adults participating in a randomized, double-blind, single-dose, four-way (placebo; loperamide 8 mg [therapeutic]; loperamide 48 mg [supratherapeutic]; moxifloxacin 400 mg [positive control]) crossover study. The electrocardiographic measurements extracted from 12-lead digital Holter recordings were time-matched to pharmacokinetic sampling of loperamide/M1.
View Article and Find Full Text PDFBackground: Intrabdominal pressure (IAP) is an important parameter. Elevated IAP can reduce visceral perfusion, lead to intraabdominal hypertension, and result in life-threatening abdominal compartment syndrome. While ingestible capsular devices have been used for various abdominal diagnoses, their application in continuous IAP monitoring remains unproven.
View Article and Find Full Text PDFArthroscopy
January 2025
Fellowship Director Emeritus, Plano Orthopedic and Sports Medicine Center, Plano Texas.
A free-floating disc shaped polycarbonate-urethane ultra-high molecular weight polyethylene fiber reinforced medial compartment implant is designed for symptomatic postmedial meniscectomy syndrome. Because it is not sutured into place, an intact 2mm meniscus rim with intact anterior and posterior meniscal horns are required. In a recent 24-month follow-up study, only 64% of the original implants were retained.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
January 2025
From the The University of Chicago Department of Orthopaedic Surgery, Chicago, IL.
Introduction: The purpose of this study was to review rates of infection after civilian ballistic fractures and assess the effect of early antibiotic administration (EAA) on infection rates.
Methods: This was a retrospective cohort study done at an urban Level 1 Trauma Center. Patients ages 16 years and older with ballistic orthopaedic extremity injuries between May 2018 and December 2020 were enrolled.
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