AI Article Synopsis
- NETosis is an immune response where neutrophils release NETs, DNA fibers with anti-microbial proteins, to trap and kill microbes.
- Cancer cells release IL-8, which activates NET release, making it possible to re-engineer NETs for tumor treatment.
- The study shows that NETs decorated with a specific protein can effectively induce cell death in tumor cells while maintaining their ability to combat infections.
Article Abstract
Background: NETosis is an innate immune response elicited by activated neutrophils to fight microbial infections. Activated neutrophils release DNA fibers decorated with anti-microbial proteins called neutrophil extracellular traps (NETs) into the extracellular space to trap and kill surrounding microbes.
Methods: Here, we show that tumor-derived IL-8 released by cancer cells also activates the release of NETs. Until now, there have been no existing technologies that leverage NETs as an anti-tumor drug delivery vehicle. In this study, we demonstrate the re-engineering of neutrophils to express an apoptosis-inducing chimeric protein, supercharged eGFP-TRAIL, on NETs that can ensnare and kill tumor cells while retaining their anti-microbial capabilities.
Results: We observed significant TRAIL-induced apoptosis in tumor cells captured by TRAIL-decorated NETs.
Conclusions: This work demonstrates NETs as a promising technology to deliver protein in response to local cytokine signals.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479081 | PMC |
| http://dx.doi.org/10.1007/s12195-020-00639-8 | DOI Listing |
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