The present study aimed to investigate the potential association between (a ) positive state and chronic cough. A clinical observational study with systematic analysis was performed, including 278 patients with complaints of chronic cough and 148 healthy controls. a positive state was present in 61.2% of the patients in the chronic cough group and 68.9% in the chronic refractory cough group, as opposed to 43.9% in the control group. There was a significant improvement in 65.5% of the patients with chronic refractory cough following successful a eradication therapy. In addition, patients with chronic cough exposed to a exhibited decreased pulmonary function with a decrease in forced expiratory volume in 1 sec by 84 ml, a decrease in the forced vital capacity by 53 ml and a decrease in maximal vital capacity by 46 ml. The difference was even more obvious in the chronic refractory cough group. The allergy status differed significantly according to age between a -positive and -negative cases in the cough variant asthma and allergic cough groups. Among patients aged <40 years, a -positive cases had a lower prevalence of atopy and lower total serum immunoglobin E levels compared with a -negative cases. However, there was no significant association between a status and C-reactive protein levels, erythrocyte sedimentation rate or eosinophil count in the peripheral blood. In conclusion, the present study demonstrated that a infection may be a factor associated with chronic cough and it may be associated with a decline in pulmonary function and reduced incidence of allergic conditions. Thus, a may represent a target for the treatment of chronic cough.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480139PMC
http://dx.doi.org/10.3892/etm.2020.9176DOI Listing

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