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comparison of treatments and commercially available solutions on mortality of third-stage larvae. | LitMetric

comparison of treatments and commercially available solutions on mortality of third-stage larvae.

Parasitology

Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili St., Hilo, HI96720, USA.

Published: February 2021

AI Article Synopsis

  • The text discusses a rise in neuroangiostrongyliasis cases on Hawai'i Island linked to consuming snails or slugs containing the larvae of the Angiostrongylus cantonensis parasite.
  • Researchers tested over 40 treatments to find an effective washing solution for fruits and vegetables to reduce exposure to this parasite, using both motility and a staining assay to assess larval mortality.
  • The study found that most consumer washes and botanical extracts were ineffective, while alkaline solutions and certain oxidizers showed promise, particularly dodecylbenzene sulfonic acid, which effectively killed the larvae.

Article Abstract

On Hawai'i Island, an increase in human neuroangiostrongyliasis cases has been primarily associated with the accidental ingestion of Angiostrongylus cantonensis L3 in snails or slugs, or potentially, from larvae left behind in the slug's slime or feces. We evaluated more than 40 different treatments in vitro for their ability to kill A. cantonensis larvae with the goal of identifying a safe and effective fruit and vegetable wash in order to reduce the risk of exposure. Our evaluation of treatment lethality was carried out in two phases; initially using motility as an indicator of larval survival after treatment, followed by the development and application of a propidium iodide staining assay to document larval mortality. Treatments tested included common household products, consumer vegetable washes and agricultural crop washes. We found minimal larvicidal efficacy among consumer-grade fruit and vegetable washes, nor among botanical extracts such as those from ginger or garlic, nor acid solutions such as vinegar. Alkaline solutions, on the other hand, as well as oxidizers such as bleach and chlorine dioxide, did show larvicidal potential. Surfactants, a frequent ingredient in detergents that lowers surface tension, had variable results, but dodecylbenzene sulfonic acid as a 70% w/w solution in 2-propanol was very effective, both in terms of the speed and the thoroughness with which it killed A. cantonensis L3 nematodes. Thus, our results suggest promising directions for future investigation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11010055PMC
http://dx.doi.org/10.1017/S0031182020001730DOI Listing

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