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Intra-axial Cortical-Based Tumour Presented as Homonymous Hemianopia in a Young Patient: A Diagnostic Dilemma.
Cureus
July 2024
Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.
Intra-axial cortical-based tumours are rare tumours affecting children and young adults. These tumours can be classified as either low-grade or high-grade, depending on their aggressiveness and rate of growth. We report a case of homonymous hemianopia secondary to an intra-axial cortical-based tumour in a young patient.
View Article and Find Full Text PDFDiffuse leptomeningeal glioneuronal tumor with distinct neuronal and glial components but identical diagnostic molecular and genetic features.
Neuropathology
December 2024
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
The 2021 World Health Organization (WHO) classification of the central nervous system (CNS) tumors has classified diffuse leptomeningeal glioneuronal tumor (DLGNT) as a mixed neuronal and glial tumor. Here, we report a DLGNT with two distinct morphological tumor components but identical molecular features. A four-year-old female child presented with progressive right upper extremity weakness.
View Article and Find Full Text PDFDiffuse Gliomas with :: Fusion: Morphological and Molecular Features and Classification Challenges.
Cancers (Basel)
April 2024
Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
:: fusion is a driver, potentially targetable, genetic alteration identified in approximately 4% of high-grade diffuse gliomas and rare cases with low-grade histology. Herein, we review the genetic and epigenetic features of these tumors and highlight the challenges in their classification and grading. Diffuse gliomas with :: fusion display unique histopathological and molecular features, including an oligodendroglioma-like appearance, calcifications, and CD34 extravascular immunoreactivity.
View Article and Find Full Text PDFDiagnostic accuracy of anti-3-[F]-FACBC PET/MRI in gliomas.
Eur J Nucl Med Mol Imaging
January 2024
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Purpose: The primary aim was to evaluate whether anti-3-[F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.
Methods: In this prospective study, patients with suspected primary or recurrent gliomas were recruited from two sites in Norway and examined with PET/MRI prior to surgery.
Freiburg Neuropathology Case Conference : Recurrent Speech Arrest, Neologistic Jargon Aphasia, and Impaired Memory Function in a 39-year-old Patient.
Clin Neuroradiol
September 2023
Department of Neuroradiology, Medical Centre-University of Freiburg, Breisacherstraße 64, 79106, Freiburg, Germany.
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