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| http://dx.doi.org/10.1136/bmjoq-2020-001108 | DOI Listing |
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Adaptive Intervention for School-Age, Minimally Verbal Children With Autism Spectrum Disorder in the Community: Primary Aim Results.
J Am Acad Child Adolesc Psychiatry
January 2025
University of Michigan, Ann Arbor, MI, USA.
Objective: The goal of this study is to construct a 16-week, two-stage, adaptive intervention consisting of DTT ([discrete trials training], largely considered usual care for children with autism), JASP-EMT (a blended, naturalistic, developmental behavioral intervention involving JASPER [joint attention, symbolic play, engagement and regulation] and EMT [enhanced milieu teaching]), and parent training (P) for improving spontaneous, communicative utterances in school-aged, minimally verbal autistic children. Intervention was delivered both at school (DTT, JASP-EMT) and home (P). This manuscript reports results for the study's primary aim and a closely related secondary aim.
View Article and Find Full Text PDFAn Investigation into the Public's Attitude Toward Opting out of Brain Death.
Neurocrit Care
January 2025
Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
Background: There have been growing sentiments that the Uniform Determination of Death Act needs to be revised. One suggestion is to include a conscience clause, that is, allowing patients to "opt-out" of brain death determination. Understanding public attitudes toward a conscience clause may help inform policymakers and future proposed revisions.
View Article and Find Full Text PDFBlood samples for ammonia analysis do not require transport to the laboratory on ice: a study of ammonia stability and cause of ammonia increase in samples from patients with hyperammonaemia.
Clin Chem Lab Med
January 2025
Department of Blood Sciences, Newcastle upon Tyne Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle Upon Tyne, NE1 4LP, UK.
Objectives: Prompt recognition of hyperammonaemia can avoid severe consequences of delayed treatment. Strict sample transport requirements present barriers to requesting and, if not achieved, rejection by the laboratory. Evidence is sparse on ammonia stability from studies using modern techniques or based in clinical settings.
View Article and Find Full Text PDFHalf-Life Extension of the IgG-Degrading Enzyme (IdeS) Using Fc-Fusion Technology.
Eur J Immunol
December 2024
Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université Paris Cité, Paris, France.
Imlifidase (IdeS) is a bacterial protease that hydrolyzes human IgG in their hinge region, decreasing their half-life and abrogating their Fc-mediated properties. It is now successfully used in therapy to prevent graft rejection during kidney transplants and is being clinically evaluated in several IgG-mediated autoimmune diseases. IdeS short half-life however limits its clinical use, particularly in the case of chronic diseases that would request repeated administrations.
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