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Salivary Metabolomics as a Diagnostic Tool: Distinct Metabolic Profiles Across Orofacial Pain Subtypes.
Int J Mol Sci
March 2025
Department of Oral Medicine, Sedation and Imaging, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, P.O. Box 12272, Jerusalem 91120, Israel.
Orofacial pain (OFP) includes chronic pain conditions categorized into musculoskeletal (MS), neurovascular (NV), and neuropathic (NP) pain types, encompassing temporomandibular disorders (TMD), migraines, trigeminal neuralgia (TN), post-traumatic neuropathies, and burning mouth syndrome (BMS). These conditions significantly affect quality of life; yet, their underlying metabolic disruptions remain inadequately explored. Salivary metabolomics provides a non-invasive method to investigate biochemical alterations associated with OFP subtypes.
View Article and Find Full Text PDFStigmatizing attitudes toward people with migraine by people without active migraine: results of the OVERCOME (US) study.
BMC Neurol
March 2025
Montefiore Headache Center, Albert Einstein College of Medicine, Bronx, US.
Background: Migraine is associated with various types of stigma. This study aims to evaluate stigmatizing attitudes towards people with migraine by people without active migraine.
Methods: OVERCOME (US) was a web survey among adults from a representative US population-based sample that collected information about stigmatizing attitudes of people without active migraine (i.
Headache types and characteristics in patients with Amyotrophic Lateral Sclerosis.
J Headache Pain
March 2025
Neurology and Psychiatry Department, Faculty of Medicine Ain Shams University, Cairo, 11566, Egypt.
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neurons, this result in muscle denervation, atrophy and consequently death takes place due to respiratory failure within 3-5 years of onset of symptoms.
Our Aim: Was to investigate types and frequency of headache in ALS patients.
Methods: This is cross sectional hospital based study.
Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China.
Int Psychogeriatr
March 2025
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; International Research Center for Medicinal Administration, Peking University, Beijing 100191, China.
To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of antidepressant prescriptions written by primary care physicians. Setting participants: Patients aged 18 years and above in 67 PHFs in Dongcheng district in Beijing between 1 January 2014 and 31 December 2022.
View Article and Find Full Text PDFSingle-centre, randomised and double-blind clinical trial on the efficacy of transcutaneous auricular vagus nerve stimulation in preventing and treating primary headache in children and adolescents: a study protocol.
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
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