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Transcriptional Regulator YqeI, Locating at ETT2 Locus, Affects the Pathogenicity of Avian Pathogenic . | LitMetric

Transcriptional Regulator YqeI, Locating at ETT2 Locus, Affects the Pathogenicity of Avian Pathogenic .

Animals (Basel)

Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei 230036, Anhui, China.

Published: September 2020

AI Article Synopsis

Article Abstract

Avian pathogenic (APEC) is the leading cause of systemic infections in poultry worldwide and has a hidden threat to public health. type three secretion system 2 (ETT2), similar to the pathogenicity island SPI1, is widely distributed in APEC and associated with virulence. The function of YqeI, which is one of the hypothetical transcriptional regulators locating at the ETT2 locus of APEC, is unknown. In this study, we successfully obtained the mutant strain AE81Δ of the wild type strain AE81 and performed the transcriptional profiling assays. Additionally, the transcriptional sequencing results revealed that YqeI influenced localization, locomotion and biological adhesion and so on. The transmission electron microscope observation showed that the wild type strain AE81 possessed long curved flagella, whereas the mutant strain AE81Δ hardly had any. The strain AE81Δ exhibited lower motility than AE81 after culturing the dilute bacterial suspension on a semisolid medium. It was also found that the survival ability of AE81Δ weakened significantly when AE81Δ was cultured with 0%, 10%, 20%, 30%, 40% and 50% SPF serum in PBS, and AE81Δ had decreased adherence to DF-1 cells compared with AE81 in the bacterial adhesion assay. The bacterial colonization assay indicated that the virulence of AE81Δ was reduced in the heart, liver, spleen, and lung. These results confirmed that the transcription regulator YqeI is involved in APEC's pathogenicity, and this study provides clues for future research.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552227PMC
http://dx.doi.org/10.3390/ani10091658DOI Listing

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