Objective: The aims of this study were to describe the perioperative course of untreated overactive bladder (OAB) (urinary frequency [UF] and urgency urinary incontinence [UUI]) before and after isolated retropubic midurethral sling (MUS) and to identify the time point for spontaneous OAB symptom improvement in the most patients.
Methods: This is a prospective cohort study of women undergoing an isolated MUS. Women completed the Urogenital Distress Inventory 6 and Incontinence Impact Questionnaire 7 preoperatively and weekly for 13 weeks postoperatively. Bothersome UF and UUI were defined as a response of "moderately" or "greatly" bothered on questions 1 and 2 of the Urogenital Distress Inventory. The treatment for OAB was deferred until 13 weeks after surgery.
Results: Fifty-four women were included with a mean ± SD age of 48 ± 9 years. Preoperatively, 41% of women reported both bothersome UF and UUI. Six weeks after surgery, only 15% and 6% reported bothersome UF and UUI (P < 0.001 and P < 0.001, respectively). Between 6 and 13 weeks, percentages of bothersome symptoms remained low (11.7% UF and 5.8% UUI). In addition, the impact of these urinary symptoms on activities, relationships, and feelings became consistently negligible (Incontinence Impact Questionnaire 7 median score <1) at 5 weeks postoperatively. Only 3 women desired treatment for UUI after the study period.
Conclusions: Overactive bladder is common before and immediately after MUS. However, the majority of patients have spontaneous symptom resolution by 6 weeks after surgery; it may be reasonable to discontinue preoperatively initiated overactive bladder treatment or defer starting treatment until this time point.
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http://dx.doi.org/10.1097/SPV.0000000000000927 | DOI Listing |
Front Glob Womens Health
December 2024
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Background: Studies on lower urinary tract symptoms (LUTS) in women, especially in relation to different modes of delivery, are limited. The relationship between the emergence of LUTS and the decline of pelvic muscle function after childbirth remains uncertain.
Study Design: This observational study was carried out at the Peking University First Hospital over a time span of 2019-2022.
Sex Reprod Healthc
September 2024
University of Texas Southwestern Medical Center, Department of Obstetrics and Gynecology, Dallas, TX, United States.
Objective: Identify factors associated with persistent sexual dysfunction and pain 12-months postpartum in an underserved population.
Methods: Extending Maternal Care After Pregnancy (eMCAP) is a program addressing health needs/disparities of patients at risk for worse perinatal outcomes. Participants completed the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) and Urinary Distress Index (UDI-6) 12-months postpartum.
Urogynecology (Phila)
April 2024
From the Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX.
Importance: Urinary incontinence is a common postpartum morbidity that negatively affects quality of life.
Objective: This study aimed to identify factors associated with persistent (ie, 12 months postpartum) bothersome urinary symptoms, including stress urinary incontinence (SUI) and urgency urinary incontinence (UUI), and explore their association with mental health in medically underserved communities.
Study Design: This was a cross-sectional analysis of a prospective study of individuals enrolled into "extending Maternal Care After Pregnancy," a program providing 12 months of postpartum care to individuals with health disparities.
Neurourol Urodyn
January 2023
Duke University Medical Center, Durham, North Carolina, USA.
Urogynecology (Phila)
January 2023
Clinical Research Consulting, Milford, CT, USA.
Importance: The international phase 3 EMPOWUR trial demonstrated efficacy and safety of vibegron, a newer β 3 -adrenergic receptor agonist, in adults with overactive bladder (OAB). Women are disproportionately affected by OAB, especially those with bothersome symptoms, such as urge urinary incontinence (UUI).
Objective: This subgroup analysis from EMPOWUR assessed efficacy and safety of vibegron in women.
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