PARP enzymes are increasingly taking on important roles beyond DNA repair. Huang et al. (2020b) report how the NAD-dependent ADP-ribosylation of histone H2B by PARP-1 in complex with a metabolic enzyme suppresses the phosphorylation of an adjacent residue, impacting adipogenesis.
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| http://dx.doi.org/10.1016/j.molcel.2020.08.019 | DOI Listing |
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