Leveraging synthetic chlorins for bio-imaging applications.

Chem Commun (Camb)

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. and Department of Chemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY 10065, USA.

Published: October 2020

Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907923PMC
http://dx.doi.org/10.1039/d0cc05494aDOI Listing

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