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Hematologic Parameters Cut-off Assessment of Adult Alpha-Thalassemia Patients in Iran.
Int J Hematol Oncol Stem Cell Res
October 2024
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Thalassemia is one of the most common blood disorders in Iran. Alpha-thalassemia is caused by the deletion of the alpha-globin gene. The frequency of deletions in the alpha-globin gene is associated with microcytosis and hypochromia, making hematological parameters valuable predictive tools in the initial identification of alpha-thalassemia patients.
View Article and Find Full Text PDFPrediction of hospitalization time probability for COVID-19 patients with statistical and machine learning methods using blood parameters.
Ann Med Surg (Lond)
December 2024
Department of Computer Science, Faculty of Mathematical Sciences, University of Guilan, Rasht, Iran.
Objectives: Coronavirus disease 2019 (COVID-19) may induce life-threatening complications and lead to death in the patients.
Method: The aim of this study was to describe a predictive model for the disease outcome (length of hospitalization and mortality) by using blood parameters results at the admission time of 201 patients with positive RT-PCR test for the infection. Variables including; age, sex, comorbidity risk factors, the length of hospitalization, and 25 blood parameters results at the time of admission were considered.
Marked microcytosis and increased transferrin saturation: Think about variants in SLC11A2 (DMT1).
Blood Cells Mol Dis
February 2025
Service d'hémato-oncologie pédiatrique, Hôpital l'Archet, Nice, France.
Congenital microcytic anemias are rare diseases associated with decreased hemoglobin synthesis and red blood cells of low corpuscular volume. DMT1/NRAMP2 is a highly conserved divalent cation transporter encoded by the SLC11A2 gene, expressed at the membrane of various cells. It ensures ferrous iron absorption from the apical membrane of enterocytes, iron recovery from urine by renal tubules, and acidified endosome uptake after transferrin internalization.
View Article and Find Full Text PDFA Comprehensive Analysis of Clinical Presentations, Laboratory Findings, and Etiologies of Pancytopenia: A Tertiary Care Experience.
Cureus
November 2024
Ear, Nose, and Throat, Doncaster Royal Infirmary, Doncaster, GBR.
Background Pancytopenia, while a common manifestation of a multitude of diseases, remains a relatively lesser-researched topic, especially in developing countries. Its management depends largely on identifying the etiology, which can range from simple infections to more sinister causes like leukemia. This study aims to investigate the clinical presentations, hematological findings, and etiologies of pancytopenia in a developing country.
View Article and Find Full Text PDFSickle cell disease (SCD) is a prevalent inherited blood disorder arising from a single point mutation that results in substitution of valine with glutamic acid in the Beta hemoglobin chain, making red blood cells assume a banana shape under low oxygen state. It is most prevalent in sub-Saharan Africa, affecting approximately 2% of the population in Mali. This study aimed to evaluate the iron status and associated hematological parameters in SCD patients at steady state in an environment with a high prevalence of iron deficiency.
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