AI Article Synopsis
- Gastric cancer (GC) is a leading cause of cancer-related deaths globally, with many cases diagnosed at advanced stages despite improvements in diagnosis and treatment.
- Non-coding RNAs (ncRNAs), particularly microRNAs and long non-coding RNAs, have been found to significantly influence the development and tumorigenesis of GC.
- The Wnt signaling pathway plays a key role in GC's pathogenesis, and ncRNAs may serve as promising biomarkers for diagnosis, prognosis, and targeted therapies by affecting tumor behavior and resistance to treatments through this pathway.
Article Abstract
Gastric cancer (GC) is one of the most common causes of cancer‑related mortality worldwide. Despite remarkable progress in the diagnosis and treatment of GC, a large number of cases are diagnosed as advanced GC, and treatment failure occurs. Emerging evidence has shown that non‑coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non‑coding RNAs (lncRNAs), play a vital role in the tumorigenesis and development of GC. Moreover, the pathogenesis of GC is closely related to aberrant activation of the Wnt (Wingless‑type MMTV integration site family) signaling pathway. ncRNAs serve as potential novel biomarkers in the clinical examination, prognosis and therapeutic targeting of GC. Furthermore, dysregulation of ncRNAs has been demonstrated to affect tumor initiation, epithelial‑mesenchymal transition (EMT), angiogenesis, tumor development, invasion, metastasis and resistance to therapy via the Wnt/β‑catenin signaling pathway. This review focuses on the role of ncRNAs in modulating the Wnt/β‑catenin signaling pathway in the pathogenesis of GC, which may provide a reference for the clinical diagnosis and treatment of GC.
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| http://dx.doi.org/10.3892/or.2020.7705 | DOI Listing |
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