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PHOSPHOINOSITIDES AND CALCIUM SIGNALING. A MARRIAGE ARRANGED IN ER-PM CONTACT SITES. | LitMetric
Calcium (Ca) ions are critically important in orchestrating countless regulatory processes in eukaryotic cells. Consequently, cells tightly control cytoplasmic Ca concentrations using a complex array of Ca-selective ion channels, transporters, and signaling effectors. Ca transport through various cellular membranes is highly dependent on the intrinsic properties of specific membrane compartments and conversely, local Ca changes have profound effects on the membrane lipid composition of such membrane sub-domains. In particular, inositol phospholipids are a minor class of phospholipids that play pivotal roles in the control of Ca-dependent signaling pathways. In this review, we will highlight some of the recent advances in this field as well as their impact in defining future research directions.
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