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Similar Publications
Hepatoprotective effect of methanol fruit extract of L in highly active antiretroviral therapy-induced toxicity in Wistar rats.
Drug Chem Toxicol
March 2024
Department of Science Technical and Vocational Education, Makerere University, Kampala, Uganda.
Article Synopsis
- Prolonged use of Highly Active Antiretroviral Therapy (HAART) can cause liver toxicity, with limited treatment options for hepatic cell regeneration.
- A study assessed the protective effects of Methanol fruit extract (MFEPG) on rats undergoing HAART, revealing that MFEPG helped restore normal liver function and reduced oxidative damage indicators.
- The findings suggest that MFEPG has antioxidant properties capable of mitigating HAART-induced liver injury, but further research is necessary to confirm its safety and efficacy.
Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.
Hepatology
July 2023
Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Article Synopsis
- Drug-induced liver injury, often caused by drugs like acetaminophen, can be severe, and the study examines how the pattern recognition receptor A (SRA) influences this process through immune interactions.
- Mice lacking SRA show increased sensitivity to liver damage, which is linked to reduced levels of the protective cytokine IL-10 and heightened liver inflammation.
- The research suggests that SRA plays a critical role in protecting the liver by promoting IL-10 production in immune cells, pointing to potential new approaches for treating drug-induced liver injuries.
Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia-Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability.
Anesth Analg
March 2023
From the Department of Anesthesiology and Pain Medicine, Malignant Hyperthermia Investigation Unit, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
Article Synopsis
- Patients with malignant hyperthermia (MH) can experience myopathy symptoms like muscle pain and fatigue outside of anesthesia, and oral dantrolene might help alleviate these symptoms, but high doses can cause liver damage.
- A study of 476 MH-susceptible patients showed that 164 received dantrolene, with mild to moderate side effects reported in 28% and 13% discontinuing treatment due to these effects or lack of improvement.
- Most patients (87%) adhered to the therapy and reported improvements, especially those with a history of MH, highlighting the effectiveness of dantrolene for certain patients despite some adverse effects.*
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