Background And Objectives: , a late colonizer of the periodontal biofilm, has been strongly associated with the chronic form of periodontitis. The aim of this study was to investigate the effects of a Dual Zinc plus Arginine formulation (aqueous solution and dentifrice) on the pathogenic properties of and the barrier function of an gingival epithelium model.
Results: The Dual Zinc plus Arginine aqueous solution and dentifrice inhibited the hemolytic and proteolytic activities of . The Dual Zinc plus Arginine aqueous solution and dentifrice enhanced the barrier function of an gingival epithelium model as determined by a time-dependent increase in transepithelial electrical resistance and decrease in paracellular permeability. This was associated with an increased immunolabeling of two important tight junction proteins: zonula occludens-1 and occludin. The deleterious effects of on keratinocyte barrier function as well as the ability of the bacterium to translocate through a gingival epithelium model were attenuated in the presence of either Dual Zinc plus Arginine aqueous solution or dentifrice.
Conclusions: The Dual Zinc plus Arginine formulation may offer benefits for patients affected by periodontal disease through its ability to attenuate the pathogenic properties of and promote keratinocyte barrier function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482904 | PMC |
| http://dx.doi.org/10.1080/20002297.2020.1798044 | DOI Listing |
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