AI Article Synopsis
- Some patients with specific genetic conditions might have a risk of a condition called postoperative pancreatic exocrine insufficiency (PPEI) after surgery to remove pancreatic tumors.
- A study looked at 82 patients who had this surgery at a research hospital over 12 years and found that 6 of them developed PPEI.
- The surgery style called pancreaticoduodenectomy (PD) was a major factor that increased the risk of PPEI, so doctors should talk about this risk with patients before they have the surgery.
Article Abstract
Background: The risk of postoperative pancreatic exocrine insufficiency (PPEI) is unknown in patients with multiple endocrine neoplasia type I (MEN1) and von Hippel-Lindau (VHL) who require resection of pancreatic neuroendocrine tumors (PNETs).
Methods: A retrospective review of patients who underwent resection of PNETs at the National Institutes of Health from 2007 to 2019 was performed.
Results: Our cohort included 82 patients (VHL n = 25, MEN1 n = 20, sporadic n = 37), 6 of whom developed PPEI. While VHL compared to all non-VHL patients (p = 0.046), non-functional PNETs (p = 0.050), and pancreaticoduodenectomy (PD) (p=<0.001) were associated with higher rates of PPEI on univariate analysis, only PD was found to be an independent predictor of PPEI on multivariate analysis (OR 14.43, 95% CI 1.43-145.8, p = 0.024).
Conclusions: The rate of PPEI in patients with hereditary tumor syndromes was similar to that of sporadic PNETs. PD was independently associated with PPEI, and this increased risk should be included in preoperative counseling.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168799 | PMC |
| http://dx.doi.org/10.1016/j.amjsurg.2020.08.048 | DOI Listing |
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