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Feasibility and Safety of a Paramedic-Directed Prehospital Buprenorphine Initiation Protocol for Acute Opioid Withdrawal.
Prehosp Emerg Care
November 2024
Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota.
Article Synopsis
- The study investigates the safety and feasibility of paramedics administering buprenorphine to treat opioid withdrawal in the field without needing online medical control.
- A review of 121 cases showed that no adverse effects from the medication were reported, although some patients experienced nausea and vomiting, which were already present before treatment.
- The findings suggest that using buprenorphine prehospital is a viable option for addressing acute opioid withdrawal in patients.
Sex differences in sensitivity to fentanyl effects in mice: Behavioral and molecular findings during late adolescence.
Neurosci Lett
August 2024
School of Medicine, Brain Institute of Rio Grande do Sul, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil. Electronic address:
Purpose: Sex differences play a crucial role in understanding vulnerability to opioid addiction, yet there have been limited preclinical investigations of this effect during the transition from adolescence to adulthood. The present study compared the behaviors of male and female rodents in response to fentanyl treatment and targeted molecular correlates in the striatum and medial prefrontal cortex.
Materials And Methods: Thirty adolescent C57BL/6J mice underwent a 1-week fentanyl treatment with an escalating dose.
From Friend to Foe: A Case of Naloxone-Induced Pulmonary Edema.
Hosp Pharm
August 2024
Northwestern Medicine McHenry Hospital, McHenry, IL, USA.
Naloxone, an opioid receptor antagonist, effectively reverses opioid overdose and opioid-induced respiratory depression. A few side effects were reported after naloxone administration, including arrhythmia and pulmonary edema. Although rare, naloxone-induced pulmonary edema can be a severe and sometimes life-threatening complication requiring mechanical ventilation.
View Article and Find Full Text PDFThe Double-Edged Sword: Naloxone-Induced Noncardiogenic Pulmonary Edema.
Cureus
July 2023
Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Naloxone-induced noncardiogenic pulmonary edema (NCPE) is a scarcely reported side effect that can occur after naloxone administration. We present a case of a 46-year-old male who presented to the emergency department for further management of an opioid overdose, who developed acute hypoxic respiratory failure after several doses of naloxone. The rapid deterioration of the patient's respiratory status required increased supplemental oxygen, with plane film radiography suggesting diffuse pulmonary edema.
View Article and Find Full Text PDFNucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.
J Clin Invest
September 2023
College of Forensic Science, Key Laboratory of National Health Commission for Forensic Science, National Biosafety Evidence Foundation, Xi'an Jiaotong University, Xi'an, China.
The nucleus accumbens (NAc) is the most promising target for drug use disorder treatment. Deep brain stimulation (DBS) of NAc is effective for drug use disorder treatment. However, the mechanisms by which DBS produces its therapeutic effects remain enigmatic.
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