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Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity. | LitMetric

Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity.

Toxicol Lett

Toxicology, Translational Science, Pharmaceuticals Division, Bayer AG, Berlin, Germany. Electronic address:

Published: November 2020

AI Article Synopsis

Article Abstract

Cisplatin is a widely used chemotherapeutic agent. However, it is causing nephrotoxic side effects including a reduced glomerular filtration rate and acute kidney injury. Although kidneys can recover to an extent from the treatment, long-term damage is possible. While a lot of research is focusing on short-term effects, little is known about adverse metabolic effects in the process of recovery. In this study, male Han Wistar rats were dosed with a single intraperitoneal injection of 3 mg/kg cisplatin. Urine and kidney samples were harvested 3, 8 and 26 days after administration. Tubular injury was demonstrated through urinary biomarkers. Complementing this, mass spectrometry imaging gives insight on molecular alterations on a spatial level, thus making it well suited to analyze short- and long-term disturbances. Various metabolic pathways seem to be affected, as changes in a wide range of metabolites were observed between treated and control animals. Besides previously reported early changes in kidney metabolism, unprecedented long-term effects were detected including deviation in nucleotides, antioxidants, and phospholipids.

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Source
http://dx.doi.org/10.1016/j.toxlet.2020.09.006DOI Listing

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