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Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus.
ERJ Open Res
November 2024
Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Hôpital Bicêtre, Service d'ORL, Le Kremlin-Bicêtre, France.
Background: Recurrent infections of the nose, sinuses and ears are common problems for people with primary ciliary dyskinesia. While pulmonary exacerbations in primary ciliary dyskinesia are defined, there is no definition for ear-nose-throat exacerbations, a potential outcome for research and clinical trials.
Methods: We set up an expert panel of 24 ear-nose-throat specialists, respiratory physicians, other healthcare professionals and patients to develop consensus definitions of sinonasal and otological exacerbations in children and adults with primary ciliary dyskinesia for research settings.
Non-redundant roles of the CCR1 and CCR2 chemokine axes in monocyte recruitment during lung metastasis.
Neoplasia
January 2025
Institute of Physiology, University of Zurich, Switzerland; Comprehensive Cancer Center Zurich. Electronic address:
Article Synopsis
- Monocytes and macrophages promote cancer progression and metastasis, particularly in the lungs, through mechanisms involving specific chemokines like CCR2 and CCR1.
- Research using mice deficient in Ccr1 and Ccr2 indicated that without these receptors, monocyte recruitment towards the primary chemokine Ccl2 was impaired, leading to reduced lung metastasis in certain tumor types (MC38 and LLC1).
- The study suggests that while CCR2 handles monocyte release from bone marrow, CCR1 is crucial for their accumulation at tumor sites, indicating distinct roles for these chemokine receptors in cancer metastasis.
Next-generation IgA-SEQ allows for high-throughput, anaerobic, and metagenomic assessment of IgA-coated bacteria.
Microbiome
October 2024
Medical Microbiology Department, UMC Utrecht, Utrecht, The Netherlands.
Background: The intestinal microbiota plays a significant role in maintaining systemic and intestinal homeostasis, but can also influence diseases such as inflammatory bowel disease (IBD) and cancer. Certain bacterial species within the intestinal tract can chronically activate the immune system, leading to low-grade intestinal inflammation. As a result, plasma cells produce high levels of secretory antigen-specific immunoglobulin A (IgA), which coats the immunostimulatory bacteria.
View Article and Find Full Text PDFSolving the High-Intensity Multimodal Training Prescription Puzzle: A Systematic Mapping Review.
Sports Med Open
July 2024
Faculty of Health, School of Sport, Exercise and Rehabilitation, Human Performance Research Centre, University of Technology Sydney, Ultimo, Sydney, NSW, 2007, Australia.
Background: High-Intensity Multimodal Training (HIMT) refers to all styles of high-intensity combined aerobic, resistance and/or bodyweight exercise. Previous heterogeneity in exercise prescription and reporting in HIMT reduces the understanding of which factors should be considered when prescribing HIMT (e.g.
View Article and Find Full Text PDFDARPin-fused T cell engager for adenovirus-mediated cancer therapy.
Mol Ther Oncol
September 2024
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Bispecific T cell engagers are a promising class of therapeutic proteins for cancer therapy. Their potency and small size often come with systemic toxicity and short half-life, making intravenous administration cumbersome. These limitations can be overcome by tumor-specific expression, allowing high local accumulation while reducing systemic concentrations.
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