Extrapleural solitary fibrous tumor (ESFT) is a rare neoplasm with a variable biological behavior that may occur almost everywhere in the body, as it has been reported in head and neck, back, retroperitoneum, inguinal region and more. The diagnosis of ESFT may be challenging, especially in case of its morphological rare variants such as giant cell-rich ESFT. Fine-needle aspiration cytology (FNAC) is a rapid, poorly invasive, safe diagnostic technique, which is recently proving useful for the preoperative diagnosis of mesenchymal neoplasms. Herein we report a case of a FNAC diagnosis of giant cell-rich ESFT, focusing on its morphological and immunocytochemical characteristics, and showing how cytology may be an effective tool in the preoperative diagnosis of mesenchymal neoplasms, allowing the correct surgical management of the patient.
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Article Synopsis
- A new type of tumor called keratin-positive giant-cell rich tumor has been identified, which is associated with certain genetic fusions and displays unique immunoreactivity to keratin in its cells.
- Researchers investigated if similar keratin-positive tumors could occur in the jaws by studying 16 cases of giant cell granulomas, but found no evidence of keratin positivity in these cases.
- Although no keratin-positive giant cell-rich tumors were detected in the jaw samples, the authors suggest that further research is needed, and oral pathologists should remain vigilant for the possible occurrence of this condition.
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