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Antidepressants and risk of postural hypotension: a self-controlled case series study.
Br J Gen Pract
January 2025
UCL, London, United Kingdom.
Background Antidepressants are associated with postural hypotension (PH), but it is not typically recognised as a common adverse effect. PH is linked with serious complications in older adults (e.g.
View Article and Find Full Text PDFDiversification and recurrent adaptation of the synaptonemal complex in Drosophila.
PLoS Genet
January 2025
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where central elements are connected on two sides by the transverse filaments to the chromatin-anchoring lateral elements. Despite being found in most major eukaryotic taxa implying a deeply conserved evolutionary origin, several components of the complex exhibit unusually high rates of sequence turnover.
View Article and Find Full Text PDFA computational deep learning investigation of animacy perception in the human brain.
Commun Biol
December 2024
Brain and Cognition, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.
The functional organization of the human object vision pathway distinguishes between animate and inanimate objects. To understand animacy perception, we explore the case of zoomorphic objects resembling animals. While the perception of these objects as animal-like seems obvious to humans, such "Animal bias" is a striking discrepancy between the human brain and deep neural networks (DNNs).
View Article and Find Full Text PDFPrevalence and influencing factors of oral frailty in older adults: a systematic review and meta-analysis.
Front Public Health
December 2024
School of Nursing, University of South China, Hengyang, China.
Objective: This study aimed to conduct a systematic review and meta-analysis, assessing the pooled prevalence and influencing factors of oral frailty in older people to assist healthcare professionals in enhancing their understanding of this condition and formulating efficient interventions.
Methods: This systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement (PRISMA) guidelines. We searched PubMed, Web of Science, The Cochrane Library, Embase, CINAHL, ProQuest, the National Knowledge Infrastructure (CNKI), WAN FANG DATA, VIP Information, SinoMed and Scopus for literature published in English or Chinese from inception to June 19, 2024.
Implications of cosmologically coupled black holes for pulsar timing arrays.
Sci Rep
December 2024
Department of Physics, University of Trento, Via Sommarive 14, 38123, Povo (TN), Italy.
It has been argued that realistic models of (singularity-free) black holes (BHs) embedded within an expanding Universe are coupled to the large-scale cosmological dynamics, with striking consequences, including pure cosmological growth of BH masses. In this pilot study, we examine the consequences of this growth for the stochastic gravitational wave background (SGWB) produced by inspiraling supermassive cosmologically coupled BHs. We show that the predicted SGWB amplitude is enhanced relative to the standard uncoupled case, while maintaining the [Formula: see text] frequency scaling of the spectral energy density.
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