An analysis of delayed action cell immunology tests involved 300 patients suffering from stomatological cancers. The tests used, tuberculine, candidine, varidase and DNCB have no particular value as far as discovering the size of the tumour, the quality of eradicating treatment or its progress. On the other hand, bias in the same direction and, even more, variations in the direction of immunity in the course of evolution seem to be a reflection of the patient's immune defence potential. This immune defence potential which can be roughly assessed in this way dose not seem to be reduced by chemotherapy or increased by immunotherapy, at least judging by the criteria used.
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Microb Cell Fact
January 2025
Department of Laboratory Medicine, The Seventh Affiliated Hospital of Southern Medical University, Foshan, Guangdong, 528244, China.
Previous studies showed that the female genital tract microbiome plays a crucial role in regulating the host's immune defense mechanisms. Our previous research has shown that Lactobacillus gasseri LGV03 (L. gasseri LGV03) isolated from cervico-vagina of HPV-cleared women contributes to clearance of HPV infection and beneficially regulate immune response.
View Article and Find Full Text PDFJMIRx Med
January 2025
Department of Biochemistry and Medical Genetics, Cancer Center, University of Illinois Chicago, 900 s Ashland, Chicago, IL, 60617, United States, 1 8479124216.
Background: The causes of breast cancer are poorly understood. A potential risk factor is Epstein-Barr virus (EBV), a lifelong infection nearly everyone acquires. EBV-transformed human mammary cells accelerate breast cancer when transplanted into immunosuppressed mice, but the virus can disappear as malignant cells reproduce.
View Article and Find Full Text PDFSci Rep
January 2025
Key Laboratory of Cancer Immunotherapy of Guangdong Tertiary Education, Guangdong CAR-T Treatment Related Adverse Reaction Key Laboratory, The First Affiliated Hospital/Clinical Medical School, Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Previously, we demonstrated that natural host-defence peptide caerin 1.1/caerin 1.9 (F1/F3) increases the efficacy of anti-PD-1 and therapeutic vaccine, in a HPV16 + TC-1 tumour model, but the anti-tumor mechanism of F1/F3 is still unclear.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the temporal impact on tumor cells and the tumor microenvironment, and the nature of anti-tumor immunity post-therapy remain largely unclear. Here we report that CD4 T cells are required for durable tumor control in syngeneic murine models of glioblastoma multiforme after treatment with an oncolytic herpes simplex virus (oHSV) engineered to express IL-12.
View Article and Find Full Text PDFTrends Plant Sci
January 2025
State Key Laboratory of Wheat Improvement, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China; College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China; Shandong Engineering Research Center of Plant-Microbial Restoration for Saline-Alkali Land, Shandong Agricultural University, Tai'an, 271018, China. Electronic address:
To address the persistent challenge of cell death spread and limitation during effector-triggered immunity (ETI), we propose a 'concentric circle' model. This model outlines a regulatory framework, integrating multiple cells and diverse signaling molecules, including salicylic acid (SA), jasmonic acid (JA), and Ca. By accounting for the varying concentrations and spatiotemporal distributions of these molecules, our model aims for precision in immune defense and regulated cell death.
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