AI Article Synopsis
- HTLV-1, a virus, inserts its genetic material into the DNA of host cells as a provirus, which is crucial for studying its persistence and disease-causing effects.
- Advances in DNA sequencing technology have significantly enhanced our understanding of the HTLV-1 provirus and the human genome, including the impact of epigenetics and chromatin structure.
- The review will focus on new discoveries about how the HTLV-1 provirus contributes to the infection process.
Article Abstract
HTLV-1 inserts its viral genome into the host cellular DNA in the form of a provirus. The proviral DNA is a key to understand the persistence and pathogenesis of HTLV-1 infection. There has been a significant progress in proviral research due to technological advances on DNA sequencing.Next generation sequencing technology revolutionized our understanding of the human genome,showing how it is organized and regulated, not only by the nucleotide sequence itself but also by epigenetic features and higher-order chromatin structure. We will review recent findings regarding the role of HTLV-1 provirus in HTLV-1 infection.
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| http://dx.doi.org/10.2222/jsv.69.23 | DOI Listing |
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