This article is to alert medical mycologists and infectious disease specialists of recent name changes of medically important species of the filamentous mold species can cause localized and life-threating infections in humans. Of the 70 species that have been reported to cause infections, close to one-third are members of the species complex (FSSC), and they collectively account for approximately two-thirds of all reported infections. Many of these species were recently given scientific names for the first time by a research group in the Netherlands, but they were misplaced in the genus In this paper, we present genetic arguments that strongly support inclusion of the FSSC in There are potentially serious consequences associated with using the name for species because clinicians need to be aware that fusaria are broadly resistant to the spectrum of antifungals that are currently available.
Hydrophobic interaction chromatography (HIC) is commonly used to determine the drug-to-antibody ratio (DAR) and drug load distribution of antibody-drug conjugates (ADCs). However, identifying various DAR species separated by HIC is challenging due to the traditional use of mobile phases that are incompatible with mass spectrometry (MS). Existing approaches used to couple HIC with MS often encounter issues, such as complex instrumentation, compromised separation efficiency, and reduced MS sensitivity.
The GC hexanucleotide repeat expansion in C9ORF72 is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models of C9-ALS/FTD useful for therapeutic development has proven challenging due to the intricate interplay of genetic and molecular factors underlying this neurodegenerative disorder, in addition to species differences. This study presents a robust investigation of the cellular pathophysiology and behavioral outcomes in a previously described AAV mouse model of C9-ALS expressing 66 GC hexanucleotide repeats.
Department of Ecology, Evolution and Behaviour, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.
Gephyrocapsa huxleyi is a prevalent, bloom-forming phytoplankton species in the oceans. It exhibits a complex haplodiplontic life cycle, featuring a diploid-calcified phase, a haploid phase and a third 'decoupled' phase produced during viral infection. Decoupled cells display a haploid-like phenotype, but are diploid.
Density functional theory (DFT) calculations indicate that [Co(HO)] reacts with two HO molecules to form [(HO)Co(OOH)(HO)] reactant complexes, which decompose through three distinct pathways depending on the relative orientation between the coordinated OOH and HO ligands. The reactive intermediates produced via these activation pathways include hydroperoxyl (OOH)/superoxide (O) radicals, singlet oxygen (O), and Co(III) species [(HO)Co(O)], [(HO)Co(OH)], and [(HO)Co(OH)]. The Co(III) species display from moderate to strong oxidizing abilities that have long been overlooked.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
X-ray crystallography is a fundamental technique that provides atomic-level insights into RNA structures. However, obtaining crystals of RNA structures diffracting to high resolution is challenging. We introduce a simple strategy to enhance the resolution limit of RNA crystals by the selective substitution of Watson-Crick pairs by GU pairs within RNA sequences.
