Globally, nearly 80 million people are forcibly displaced. Being a refugee can impact one's mental health profoundly. Although specific approaches for psychotherapy with refugees have been developed, this study is the first to investigate psychotherapy with refugees in Brazil. Semi-structured interviews were conducted with 18 psychotherapists in Brazil and analysed using consensual qualitative research and thematic analysis. Supportive and hindering elements in psychotherapy with refugee patients in Brazil were identified at eight different levels: the patient, the therapist, their relationship, the setting, the psychotherapeutic approach, the context of the patient, the context of the therapist and the societal context in Brazil. Hindering elements in the therapy include missing preparation for the integration of refugees, lack of interpreters, patients' mistrust and therapists feeling untrained, helpless and becoming overinvolved. Supportive elements include a trusting therapeutic relationship, therapists' cultural humility and structural competence, patients' societal inclusion as well as working with groups and networks. This study shows that in light of the enormous structural challenges for the mental wellbeing of refugee patients, therapists' flexibility and the reliance on collective work and networks of support is crucial. Future research might investigate in more detail notions of collectivity-based mental healthcare in intercultural therapy settings.
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http://dx.doi.org/10.1080/10503307.2020.1820596 | DOI Listing |
Int J Mol Sci
December 2024
Materials Research Institute, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Since its conceptualization, click chemistry in all its variants has proven to be a superior synthesis protocol, compared to conventional methods, for forming new covalent bonds under mild conditions, orthogonally, and with high yields. If a term like reactive resilience could be established, click reactions would be good examples, as they perform better under increasingly challenging conditions. Particularly, highly hindered couplings that perform poorly with conventional chemistry protocols-such as those used to conjugate biomacromolecules (e.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Neurotransmitter release is triggered in microseconds by Ca-binding to the Synaptotagmin-1 C-domains and by SNARE complexes that form four-helix bundles between synaptic vesicles and plasma membranes, but the coupling mechanism between Ca-sensing and membrane fusion is unknown. Release requires extension of SNARE helices into juxtamembrane linkers that precede transmembrane regions (linker zippering) and binding of the Synaptotagmin-1 CB domain to SNARE complexes through a "primary interface" comprising two regions (I and II). The Synaptotagmin-1 Ca-binding loops were believed to accelerate membrane fusion by inducing membrane curvature, perturbing lipid bilayers, or helping bridge the membranes, but SNARE complex binding through the primary interface orients the Ca-binding loops away from the fusion site, hindering these putative activities.
View Article and Find Full Text PDFmSystems
January 2025
Institute for Infection Prevention and Control, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
The surveillance of mobile genetic elements facilitating the spread of antimicrobial resistance genes has been challenging. Here, we tracked both clonal and plasmid transmission in colistin- and carbapenem-resistant using short- and long-read sequencing technologies. We observed three clonal transmissions, all containing Incompatibility group (Inc) L plasmids and New Delhi metallo-beta-lactamase , although not co-located on the same plasmid.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
Psychology Unit, IRCCS "Regina Elena" National Cancer Institute, 00144 Rome, Italy.
Background: Communication is an important aspect in making patients competent to define, process, and manage their disease condition as well as to intercept and satisfy psychosocial needs. Communication between patient and nurse is central to the learning and orientating process since the nurse has the greatest frequency and continuity of relationship with patients and their families. This study aims to investigate the quality of communication between patient and nurse and the factors that promote or hinder effective communication from the oncology patient's perspective within an inpatient hospital setting.
View Article and Find Full Text PDFNat Plants
January 2025
Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Pseudouridine (Ψ) is the most abundant RNA modification, yet studies of Ψ have been hindered by a lack of robust methods to profile comprehensive Ψ maps. Here we utilize bisulfite-induced deletion sequencing to generate transcriptome-wide Ψ maps at single-base resolution across various plant species. Integrating ribosomal RNA, transfer RNA and messenger RNA Ψ stoichiometry with mRNA abundance and polysome profiling data, we uncover a multilayered regulation of translation efficiency through Ψ modifications.
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