Further Characterization of the Pseudo-Symmetrical Ribosomal Region.

Life (Basel)

Department of Biology & Biochemistry, University of Houston, Houston, TX 77204, USA.

Published: September 2020

The peptidyl transferase center of the modern ribosome has been found to encompass an area of twofold pseudosymmetry (SymR). This observation strongly suggests that the very core of the ribosome arose from a dimerization event between two modest-sized RNAs. It was previously shown that at least four non-standard interactions exist between the two halves of SymR. Herein, we verify that the structure of the SymR is highly conserved with respect to both ribosome transition state and phylogenetic diversity. These comparisons also reveal two additional sites of interaction between the two halves of SymR and refine our understanding of the previously known interactions. In addition, the possible role that magnesium may have in the coordination, stabilization, association, and evolutionary history of the two halves (A-region and P-region) was examined. Together, the results identify a likely site where structural elements and Mg ions may have facilitated the ligation of two aboriginal RNAs into a single unit.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555685PMC
http://dx.doi.org/10.3390/life10090201DOI Listing

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