Background: Prognosis of oral squamous cell carcinoma (OSCC) is difficult to exactly assess on pre-operative biopsies. Since OSCC DNA methylation profile has proved to be a useful pre-operative diagnostic tool, the aim of the present study was to evaluate the prognostic impact of DNA methylation profile to discriminate OSCC with high and low aggressive potential.
Methods: 36 OSCC cases underwent neoplastic cells collection by gentle brushing of the lesion, before performing a pre-operative biopsy. The CpG islands methylation status of 13 gene (, , , , , , , , , , , , ) was studied by bisulfite Next Generation Sequencing (NGS). A Cox proportional hazards model via likelihood-based component-wise boosting was used to evaluate the prognostic power of the CpG sites.
Results: The boosting estimation identified five CpGs with prognostic significance: , , , and . The combination of significant provided promising results for adverse events prediction (Brier score = 0.080, C-index = 0.802 and AUC = 0.850). had a strong prognostic power in patients with early OSCC.
Conclusions: These data confirm that the study of methylation profile provides new insights into the molecular mechanisms of OSCC and can allow a better OSCC prognostic stratification even before surgery.
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| http://dx.doi.org/10.3390/ijms21186691 | DOI Listing |
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