AI Article Synopsis
- Two new compounds, pegaharmols A and B, were discovered in the roots of a plant, showcasing unique structural features as nonbiaryl axially chiral β-carboline-quinazoline dimers.
- Their structures were analyzed using advanced techniques like mass spectrometry and nuclear magnetic resonance (NMR).
- The compounds exhibited modest cytotoxic effects on cancer cell lines HL-60 and A549, and it was noted that they uniquely bond β-carboline at the C-8 position with vasicine at the C-9 position for the first time.*
Article Abstract
Two nonbiaryl axially chiral β-carboline-quinazoline dimers, pegaharmols A () and B (), were isolated from the roots of . Their planar structures were elucidated by the spectroscopic methods of high-resolution mass spectrometry and 1D and 2D nuclear magnetic resonance (NMR). The stereochemistry was established by a comparison between the experimental data of NMR and electronic circular dichroism and the computed data by quantum mechanical calculations. It is discovered for the first time that the β-carboline at the C-8 position is bonded to the vasicine at the C-9 position. exhibited moderate cytotoxic activity against HL-60 and A549 cell lines.
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| http://dx.doi.org/10.1021/acs.orglett.0c02709 | DOI Listing |
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