Anticancer and antimicrobial compounds from Gieseler and DC: Two edible plants used in the traditional medicine of the Kuki tribes.

DC and Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals () by extensive use of chromatographic and spectroscopic methods. They were also tested for cytotoxic effects against A549 and MIAPACA2 cell lines and antimicrobial activities against and All compounds showed moderate activity against the MIAPACA2 cell lines. Compounds tricosan-1-ol (), octacosanoic acid (), β-sitosterol () and -dodec-3-en-1-ol () exhibited promising activity against A549 cell lines with IC of 16.72, 4.5, 4.42 and 4.5 μg/ml respectively. Further, hexatriacontan-1-ol () exhibited lowest MIC of 50 μg/ml against and henicosan-1-ol () at 25 μg/ml against They were also screened through docking analysis against two Phosphatidylinositol-3-Kinase nodal proteins and three feedback loop proteins of cancers. Thus, this study validates their traditional uses as herbal anticancer and antimicrobial agents.