AI Article Synopsis
- The study explored how propylthiouracil affects adhesion molecules in patients with subclinical hyperthyroidism, considering a total of 168 patients treated for a year.
- Results showed that levels of sICAM-1 were significantly higher in patients compared to healthy controls, but decreased after treatment though not to control levels, while sVCAM-1 remained unchanged.
- The conclusion emphasized the need for further research to understand the implications for atherosclerosis and cancer risk in these patients.
Article Abstract
Objective: This study aimed to investigate the effect of propylthiouracil treatment on adhesion molecules in patients with subclinical hyperthyroidism.
Methods: In this study, a total of 168 patients diagnosed with subclinical hyperthyroidism were treated with propylthiouracil for one year. The levels of adhesion molecules, consisting of sICAM-1, sVCAM-1, and sE-Selectin, before and after the treatment were measured and compared. These results were compared with the levels of 148 healthy controls who received a placebo.
Results: sICAM-1 levels were significantly higher in subclinical hyperthyroidism patients than in healthy controls (*pa=0.000). sICAM-1 levels were significantly decreased after the treatment (**pb=0.000). Despite this decrease in patients with subclinical hyperthyroidism, it did not decrease to the level of the control group. sVCAM-1 did not change before and after propylthiouracil treatment. The level of sE-selectin was similar to that of the pretreatment control group, but it did not have statistical significance, although it increased after the treatment (**pb=0.004).
Conclusion: The sICAM level was significantly higher than the pretreatment values and decreased after the propylthiouracil treatment. However, further studies are needed to reduce the risk of atherosclerosis and cancer in patients with subclinical hyperthyroidism.
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| http://dx.doi.org/10.1590/1806-9282.66.8.1057 | DOI Listing |
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