AI Article Synopsis
- The COVID-19 pandemic, caused by SARS-CoV-2, exerts significant pressure on global healthcare systems, making serologic testing crucial for understanding community exposure and immune response.
- * A new laboratory-developed antibody test has been introduced that uses common research-grade materials to effectively detect past SARS-CoV-2 exposure in blood samples, demonstrating high sensitivity and specificity.
- * This test can also measure specific IgG titers from a single sample, making it a practical and cost-efficient tool for evaluating individual immune responses in the context of the ongoing pandemic.
Article Abstract
The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts is serologic testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior infection or vaccination. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. We further show that this test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual's immune response. The accuracy, adaptability, and cost-effectiveness of this test makes it an excellent option for clinical deployment in the ongoing COVID-19 pandemic.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491531 | PMC |
| http://dx.doi.org/10.1101/2020.09.10.20192187 | DOI Listing |
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