AI Article Synopsis
- The study investigated how myo-inositol levels in cord blood relate to gestational age (GA) in infants, as well as the differences in these levels between enterally and parenterally fed infants from birth to 70 days.
- Myo-inositol concentrations were measured in 441 samples from 281 infants, showing variability and a clear decline as GA and postmenstrual age (PMA) increased.
- It was found that cord myo-inositol levels decreased about 11.9% for each week of GA increase, while postnatal levels decreased about 14.3% for each week of PMA, with enterally fed infants having significantly higher levels compared to unfed infants.
Article Abstract
Objective: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age.
Design/methods: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values.
Results: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants).
Conclusions: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889639 | PMC |
| http://dx.doi.org/10.1038/s41372-020-00799-5 | DOI Listing |
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