AI Article Synopsis
- The study examines the relationship between severity of periodontitis and the CD4/CD8 lymphocyte ratio along with CMV IgG levels in patients with systemic lupus erythematosus (SLE).
- It involved 93 SLE patients and measured periodontitis severity using the periodontal index, with flow cytometry and ELISA used to assess lymphocyte ratios and IgG CMV levels.
- Results showed a significant negative correlation between the CD4/CD8 ratio and periodontitis severity, and a positive correlation between IgG CMV levels and periodontitis severity, suggesting these markers could help assess gum disease in SLE patients.
Article Abstract
Objectives: The aim of the study was to analyze the correlation between periodontitis severity in systemic lupus erythematosus (SLE) with CD4/CD8 lymphocytes ratio and cytomegalovirus gamma immunoglobulin (IgG CMV) level.
Materials And Methods: This is a descriptive study using a cross-sectional approach that included 93 subjects who were diagnosed with SLE in Rheumatology Department, Saiful Anwar Hospital, during 2017 to 2019. Periodontitis severity was assessed by periodontal Index (PI). CD4/CD8 lymphocyte ratio was determined using flow cytometry and IgG CMV levels using enzyme-linked immunosorbent assay.
Statistical Analysis: The differences among the three groups were analyzed using analysis of variance. Correlation among the groups was calculated using Spearman/Pearson correlation coefficient test, while regression analysis was done using Statistical Package for the Social Sciences.
Results: The mean of periodontitis severity and standard deviation in SLE was 2.66 ± 1.02. There were negative correlation between CD4/CD8 lymphocyte ratio with periodontal index ( = -0.971) and positive correlation between IgG CMV level with periodontal index ( = 0.977).
Conclusions: Inverted CD4/CD8 ratio and IgG CMV were found associated with periodontitis severity in SLE patient. Further research was recomended that CD4/CD8 lymphocytes ratio and IgG CMV can be used as a potensial marker of periodontitis severity in SLE patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535962 | PMC |
| http://dx.doi.org/10.1055/s-0040-1715788 | DOI Listing |
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