: The purpose of this study was to evaluate the effects of anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) on muscle endurance in the back-squat exercise. : Eleven healthy males, intermediate in resistance training (RT), aged between 18 and 31 years (25.5 ± 4.4 years) were recruited. In the initial visits (1st and 2nd visits), participants performed a 1RM test to determine the load in the back-squat exercise. Following the two initials visits, participants attended the lab for the two experimental conditions (anodal tDCS and sham), which were completed a week apart, with sessions randomly counterbalanced. The stimulation was applied over the DLPFC for 20 minutes using a 2 mA current intensity. Immediately after the experimental conditions, participants completed three sets of maximum repetitions (80% of 1RM), with a 1-minute recovery interval between each set in the back-squat exercise. Muscle endurance was determined by the total number of repetitions and the number of repetitions in each set. : The total number of repetitions was higher in the anodal tDCS condition compared to sham condition ( ≤ .0001). Moreover, the number of repetitions performed in the first set was higher for anodal tDCS condition than in the sham condition ( ≤ .01). : This study found improvement in back-squat exercise performance after the application of anodal tDCS. The effects of anodal tDCS applied over DLPFC may be a promising ergogenic resource on muscle endurance in the back-squat exercise.

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