The article presents current literature data on genetic studies of neurocognitive deficit in schizophrenia, including the genes of neurotransmitter systems (dopaminergic, glutamatergic, and serotonergic); genes analyzed in genome-wide association studies (GWAS), as well as other genetic factors related to the pathophysiological mechanisms underlying schizophrenia and neurocognitive disorders.
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http://dx.doi.org/10.17116/jnevro2020120081183 | DOI Listing |
Background: Neurodevelopmental origins of functional variation through the lifespan are acknowledged, but pathways need to be identified. The objectives of the project Set-to-change is to test whether and how early life environmental factors and genetic makeup regulate brain and cognition and its change, as well as neurocognitive plasticity in response to training through the lifespan.
Method: Preliminary analyses for the first months are presented.
Alzheimers Dement
December 2024
Neuropsychiatry, The Royal Melbourne Hospital, Parkville, VIC, Australia.
Background: Younger-onset neurocognitive symptoms result from a heterogenous group of neurological and psychiatric disorders which present a diagnostic challenge. To identify such factors, we analysed the BeYOND (Biomarkers in Younger-Onset Neurocognitive Disorders) cohort, a study of individuals less than 65 years old presenting with neurocognitive symptoms for a clinical diagnosis and who have undergone cognitive and biomarker analyses.
Method: 65 participants were recruited during their index presentation to the Royal Melbourne Hospital Neuropsychiatry Centre, a tertiary specialist service in Melbourne, Australia.
Background: Alzheimer's Disease (AD) has been associated with neurocognitive, metabolic, and neuroinflammatory alterations. Currently, there are no useful biomarkers in low-resource countries, and genetic risk/protection factors in Peruvians are unknown.
Objective: To establish the first serum bank in the northern part of the country for the analysis of participants with mild cognitive impairment (MCI) or AD.
Background: Neurocognitive trajectories in normal aging are a result of complex and synergistic associations of multiple risk domains. Blood-based, neuroimaging, and genetic biomarkers all play fundamental roles that span decades leading to cognitive decline. We study all three risk domains on memory using an ethnoracially diverse cohort.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada., Granada, Granada, Spain.
Regular exercise has been shown to have beneficial effects including reducing risk of developing Alzheimer's disease (AD). However, it is unclear if exercise has direct effects on AD pathophysiology. To this end, several emerging initiatives have been established to investigate plasma biomarker changes in relation to exercise among older adults.
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