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Atypical Plasma Cell Leukemia Mistaken for Acute Leukemia: A Case Report.
Medicina (Kaunas)
August 2024
Department of Pathology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia.
The patient we present here had many clinical, morphological, and laboratory findings characteristic of acute leukemia. During the course of the disease, the diagnosis changed from acute leukemia to chronic small B-cell lymphoproliferative disease, a blastoid variant of mantle cell lymphoma, and finally to atypical plasma cell leukemia. Atypical plasma cell leukemia is a rare condition with aggressive biological behavior.
View Article and Find Full Text PDFKidney Biopsy Un-masquerading Plasma Cell Leukemia Diagnosed as Acute Myeloid Leukemia: An Unusual Clinical Experience.
Cureus
August 2023
Medicine/Nephrology, Edward Hines, Jr. VA Hospital, Hines, USA.
Plasma cell leukemia (PCL) is a rare aggressive variant of plasma cell myeloma. The differential diagnosis of PCL includes multiple myeloma (MM), other leukemias, and lymphomas with abnormal cells circulating in the peripheral blood. In addition, infectious or autoimmune diseases can cause reactive polyclonal plasmacytosis, which could confuse us with PCL occasionally.
View Article and Find Full Text PDFBi-allelic amplification of ATM gene in blastoid variant of mantle cell lymphoma: a novel mechanism of inactivation due to chromoanagenesis?
Mol Cytogenet
February 2021
Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX, USA.
Background: Mantle cell lymphoma (MCL) is derived from naïve CD5+ B-cells with the cytogenetic hallmark translocation 11;14. The presence of additional abnormalities is associated with blastoid variants in MCL (BMCL) and confers a poor prognosis. Many of these tumors also show deletion or loss of heterozygosity (LOH) of the ATM gene and biallelic ATM inactivation show significantly higher chromosomal imbalances.
View Article and Find Full Text PDFCirculating blastoid cells: acute leukemia, prolymphocytic leukemia, or something else?
Ann Hematol
December 2021
Department of Pathology, Duke University Medical Center, DUMC Box 3712, M-345 Davison Bldg (Green Zone) Duke Hospital South, Durham, NC, USA.
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Am J Hematol
June 2019
Division of Cancer Medicine, Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the variable region of immunoglobulin heavy chain, methylation status, and SOX-11 expression. Cyclin-D1 negative MCL, in situ MCL neoplasia, and impact of the karyotype on prognosis are distinguished.
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