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| http://dx.doi.org/10.1007/s12291-020-00922-5 | DOI Listing |
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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies.
PLoS Pathog
January 2025
Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory tract. There is an unmet need for an in vivo model to study infection of different orthohantaviruses in physiologically relevant tissue and to assess the efficacy of novel pan-orthohantavirus countermeasures. Here, we describe the use of a human lung xenograft mouse model to study the permissiveness for different orthohantavirus species and to assess its utility for preclinical testing of therapeutics.
View Article and Find Full Text PDFRespiratory symptoms after coalmine fire and pandemic: A longitudinal analysis of the Hazelwood Health Study adult cohort.
PLOS Glob Public Health
January 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
The aim of this study was to determine whether the effects of extreme but discrete PM2.5 exposure from a coal mine fire on respiratory symptoms abated, persisted, or worsened over time, and whether they were exacerbated by COVID-19. We analysed longitudinal survey data from a cohort residing near a 2014 coalmine fire in regional Australia.
View Article and Find Full Text PDFStress generation and subsequent repetitive negative thinking link poor executive functioning and depression.
Anxiety Stress Coping
January 2025
Department of Psychology, Brandeis University, Waltham, MA, USA.
Background And Objective: Poor executive functioning (EF) has been consistently linked to depression, but questions remain regarding mechanisms driving this association. The current study tested whether poor EF is linked to depression symptoms six weeks later via dependent stressors (model 1) and stressors perceived to be uncontrollable (model 2) at week two (W2) and repetitive negative thinking (RNT) at W4 during early COVID-19 in college students.
Design: This was a longitudinal study with four timepoints spanning six weeks (April-June 2020).
Hospitalization and mortality in children due to COVID-19. A retrospective study from Brazil.
JMIR Pediatr Parent
January 2025
Faculdade de Medicina de Sao Jose do Rio Preto-Brazil, University of Ribeirão Preto, Brazil, Sao Jose do Rio Preto, BR.
Background: Background: COVID-19 is currently one of the most important medical challenges as it affects the entire population, with children being infected as easily as adults.
Objective: The objective of this study was to evaluate the prevalence of mortality in under 19-year-old individuals compared to that of adults.
Methods: This retrospective, observational study analyzed the medical records of all patients diagnosed with COVID-19 by real-time reverse transcription-polymerase chain reaction (RT-PCR) who were hospitalized at Hospital de Base and the Infant and Maternal Hospital of São Jose do Rio Preto, SP, Brazil.
Canadian Men's Intimate Partner Relationship Break-Ups During COVID-19: Implications for Mental Health Promotion.
Qual Health Res
January 2025
Department of Psychological Medicine, University of Otago, Dunedin, New Zealand.
COVID-19 impacted many men's intimate partner relationships, with distressed and disrupted partnerships consistently featured in commentaries with linkages to mental health challenges. The current study draws from interviews with 23 Canadian-based men, 19-50 years old, who experienced a break-up during COVID-19. Addressing the research question, "What are the connections between masculinities, men's mental health, and intimate partner relationship break-ups during COVID-19?", three thematic findings were derived: (1) Virtually Together and Growing Apart, (2) Mentally Trapped, and Failing Fast and Slow, and (3) Introspections and Moving On.
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