The SW Japan arc built by subduction of the Philippine Sea (PHS) plate exhibits uneven distribution of volcanoes: thirteen Quaternary composite volcanoes form in the western half of this arc, Kyushu Island, while only two in the eastern half, Chugoku district. Reconstruction of the PHS plate back to 14 Ma, together with examinations based on thermal structure models constrained by high-density heat flow data and a petrological model for dehydration reactions suggest that fluids are discharged actively at depths of 90-100 km in the hydrous layer at the top of the old (> 50 Ma), hence, cold lithosphere sinking beneath Kyushu Island. In contrast, the young (15-25 Ma) oceanic crust downgoing beneath Chugoku district releases fluids largely at shallower depths, i.e. beneath the non-volcanic forearc, to cause characteristic tectonic tremors and low-frequency earthquakes (LFEs) and be the source of specific brine springs. Much larger amounts of fluids supplied to the magma source region in the western SW Japan arc could build more densely-distributed volcanoes.
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http://dx.doi.org/10.1038/s41598-020-72173-6 | DOI Listing |
JCI Insight
January 2025
Department of Immunology and.
Tumor-associated macrophages (TAMs) are one of the key immunosuppressive components in the tumor microenvironment (TME) and contribute to tumor development, progression, and resistance to cancer immunotherapy. Several reagents targeting TAMs have been tested in preclinical and clinical studies, but they have had limited success. Here, we show that a unique reagent, FF-10101, exhibited a sustained inhibitory effect against colony-stimulating factor 1 receptor by forming a covalent bond and reduced immunosuppressive TAMs in the TME, which led to strong antitumor immunity.
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January 2025
Department of Neurosurgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Purpose: In this retrospective study, we aimed to evaluate the efficacy and incidence of radiation-induced brain necrosis (RBN) after volumetric modulated arc therapy-based stereotactic irradiation (VMAT-STI) for brain metastases.
Methods: In the 220 brain metastatic lesions included between January 2020 and June 2022, there were 1-9 concurrently treated lesions (median 1). A biologically effective dose (BED)10 of 80 Gy and a reduced BED10 of 50 Gy were prescribed to the gross tumor volume (GTV) and planning target volume (PTV) (PTV = GTV + 3 mm) margins, respectively.
Nature
January 2025
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Plants lack specialized and mobile immune cells. Consequently, any cell type that encounters pathogens must mount immune responses and communicate with surrounding cells for successful defence. However, the diversity, spatial organization and function of cellular immune states in pathogen-infected plants are poorly understood.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Joining and Welding Research Institute, Osaka University, Osaka 567-0047, Japan.
Narrow-gap arc welding is an efficient method that significantly enhances industrial production efficiency and reduces costs. This study investigates the application of low-alloy steel wire EG70-G in narrow-gap gas metal arc welding (GMAW) on thick plates. Experimental observations were made to examine the arc behavior, droplet transition behavior, and weld formation characteristics of double-wire welding under various process parameters.
View Article and Find Full Text PDFBiology (Basel)
November 2024
Advanced Reproductive Centre (ARC) HCTM UKM, Department of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latiff, Cheras, Kuala Lumpur 56000, Malaysia.
An overall in vitro fertilization (IVF) outcome is dynamic. Good oocyte quality is important for achieving a better IVF pregnancy. Various methods have been used for OQ assessment (OQA).
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