AI Article Synopsis
- The study aimed to investigate how fatigue relates to electrophysiological parameters and motor unit function in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
- Experienced fatigue was measured using specific scales, and various assessments were taken from 15 patients undergoing treatment, but results showed no significant correlation between fatigue levels and motor unit function.
- Ultimately, the findings suggest that fatigue in CIDP is not strongly linked to peripheral nerve dysfunction, making traditional nerve tests less effective in gauging fatigue levels in these patients.
Article Abstract
Objective: To explore the relationship between fatigue, standard electrophysiological parameters and number and size of functioning motor units in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
Methods: Experienced fatigue was assessed using the linearly-weighted, modified Rasch-built fatigue severity scale (R-FSS) and the multidimensional Checklist of Individual Strength (CIS). Averaged electrophysiology values were calculated from multiple nerves. Motor Unit Number Index (MUNIX) technique was utilised to assess motor unit function. Assessments were repeated in 15 patients receiving regular intravenous immunoglobulin therapy, with changes in parameters calculated.
Results: R-FSS and CIS scores did not correlate MUNIX or MUSIX sum scores from 3 different muscles. Inverse correlation was observed only between distal CMAP area and R-FSS but not CIS scores. However, changes in distal CMAP area and R-FSS scores on repeat assessment were not correlated.
Conclusions: Experienced fatigue does not appear to correlate with loss of functioning motor units in patients with CIDP. Changes in experienced fatigue on repeat assessment did not correlate with changes in any of the electrophysiological parameters, suggesting fatigue experienced in CIDP is not strongly correlated with peripheral nerve dysfunction.
Significance: Nerve conduction studies and MUNIX values do not appear to be useful surrogate markers for fatigue in CIDP.
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| http://dx.doi.org/10.1016/j.clinph.2020.08.011 | DOI Listing |
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