AI Article Synopsis
- - Inthomycins are a type of antibiotic derived from a bacteria called Streptomyces pactum L8, characterized by their unique chemical structure featuring a carboxamide group and a triene chain.
- - The study focused on isolating Inthomycin B and two new related compounds, along with identifying the gene cluster responsible for their biosynthesis.
- - A proposed formation mechanism for the carboxamide part of inthomycins suggests that a specific gene deletion in the biosynthesis process triggered an oxidative release that helps develop this chemical group.
Article Abstract
Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the gene cluster for inthomycin biosynthesis as well as the N-labeled glycine incorporation into inthomycins are described. Combined with the gene deletion of the rare P450 domain in the NRPS module, a formation mechanism of carboxamide moiety in inthomycins was proposed via an oxidative release of the assembly chain assisted by the P450 domain.
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| http://dx.doi.org/10.1016/S1875-5364(20)60006-1 | DOI Listing |
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