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http://dx.doi.org/10.1186/s13024-020-00403-6 | DOI Listing |
Nat Commun
January 2025
Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
The placenta is the critical interface between mother and fetus, and consequently, placental dysfunction underlies many pregnancy complications. Placental formation requires an adequate expansion of trophoblast stem and progenitor cells followed by finely tuned lineage specification events. Here, using single-cell RNA sequencing of mouse trophoblast stem cells during the earliest phases of differentiation, we identify gatekeepers of the stem cell state, notably Nicol1, and uncover unsuspected trajectories of cell lineage diversification as well as regulators of lineage entry points.
View Article and Find Full Text PDFMaterials (Basel)
November 2024
Biomedical Engineering, University of Baghdad, Baghdad 10071, Iraq.
Terahertz waves are nondestructive and non-ionizing to synthetic and natural materials, including polymeric and biological materials. As a result, terahertz-based spectroscopy has emerged as a suitable technique to uncover fundamental molecular mechanisms and material properties in this electromagnetic spectrum regime. In terahertz time-domain spectroscopy (THz-TDS), the material's optical properties are resolved using the raw time-domain signals collected from the sample and air reference data depending on accurate prior knowledge of the sample geometry.
View Article and Find Full Text PDFJ Endocrinol Invest
December 2024
Nuclear Medicine and Molecular Imaging, ICANS, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.
Purpose: To investigate the influence of germline succinate dehydrogenase (SDHx) pathogenic variants on 6-[F]-fluoro-3,4-dihydroxyphenylalanine (F-DOPA) Positron Emission Tomography (PET) radiomic signature of head and neck paragangliomas (HNPGLs).
Methods: Forty-seven patients (20 SDH pathogenic variants carriers) harboring 55 HNPGLs were retrospectively included. HNPGLs were delineated using Nestle adaptive threshold.
ACS Appl Mater Interfaces
December 2024
School of Electronic Science and Engineering, Southeast University, Nanjing 210096, People's Republic of China.
The dynamic time-gating anticounterfeiting based on phosphorescence materials is the current hot topic of research. However, the short change time from nanosecond-level fluorescence false information to μs-level fluorescence correct information makes it easily deciphered just by turning off ultraviolet (UV) light. Herein, we first reported a new type of minute-level dynamic time-gating anticounterfeiting technology based on the ethanol-induced phase transition between the red-emitting CsMnBr crystals and green-emitting CsMnBr crystals.
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