Objective: The Anastomotic Coupling Device for microvascular anastomoses has become widely used in free tissue transplantation. This study compares the thrombosis rate and flap failure as a function of the anastomosis technique at a large head and neck cancer center.
Material And Methods: Retrospective analysis of all patients receiving free flap reconstructions in the period 2001-2019. Reconstruction type, recipient vessels, number of venous anastomoses, coupler size, and operation time were investigated. We compared the rates of venous thrombosis between hand sewn and coupled anastomoses, as well as the rate of flap failure.
Results: A total of 403 free flap reconstructions were performed for over 17 years. The venous anastomosis was sewn in 113 flaps in single suture technique, and in 290 cases, coupler device was used. The rate of venous thrombosis requiring immediate surgical revision was 6.2 % (7/113) in the sewn group compared to 7.6 % in the coupled group (22/290; p = 0.627). With an overall success rate of 95.0 % (383/403), the rate of flap failure was 3.6 % (4/113) and 5.5 % (16/290; p = 0.421), respectively. Surgical time is comparable with 680 ± 144 minutes in the hand-sewn group and 688 ± 167 minutes in the coupled group (p = 0.678).
Conclusions: With similar success rates, the coupler device is an effective alternative to venous anastomosis in single suture technique. Due to the generally low rate of pedicle thrombosis in both groups, we cannot separate the influence of the anastomosis technique from possible interfering variables.
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http://dx.doi.org/10.1055/a-1253-8392 | DOI Listing |
Ann Chir Plast Esthet
January 2025
Plastic and Reconstructive Surgery, hôpital Conception, 147, boulevard Baille, 13005 Marseille, France.
Introduction: Fournier's gangrene is a severe infection of the perineum and genital regions, with high mortality rate. Treatment is medico-surgical and multidisciplinary, usually requiring extensive debridement of scrotal tissue and distant surgical reconstruction. Regarding scrotal reconstruction, numerous techniques have been described, however, to our knowledge, none has focused on testicular repositioning.
View Article and Find Full Text PDFEur J Surg Oncol
January 2025
Division of Breast Surgery, General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taipei and Taoyuan City, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan.
Objective: This study aimed to compare the surgical and oncological outcomes of robotic mastectomy (RM) and conventional mastectomy (CM) for breast cancer.
Methods: Our institutional registry of women with breast cancer who received RM between 2018 and 2023 and CM between 2016 and 2023 were reviewed. Propensity score matching of clinicopathological variables was used to match 123 RM patients with 123 CM patients.
Acta Otolaryngol
January 2025
Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey.
Background: Endoscopic transcanal butterfly cartilage myringoplasty is a prominent procedure because surgeons can perform this operation without elevating the transmeatal flap.
Objective: To evaluate factors that affect endoscopic butterfly cartilage myringoplasty regarding graft success and hearing improvement and determine long-term outcomes.
Materials And Methods: This study included 86 patients who underwent surgery.
ACS Infect Dis
January 2025
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising antibiotic target. This enzyme catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), which is the rate-limiting step in guanine nucleotide biosynthesis. Bacterial IMPDH-specific inhibitors have been developed that bind to the NAD site.
View Article and Find Full Text PDFMicrosurgery
February 2025
Plastic and Reconstructive Surgery, Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
Background: Scalp reconstruction is a challenging field for plastic surgeons. In case of large or complex defects, microsurgical-free flaps are usually required. Reconstructive failure can result in high morbidity and in some cases be life-threatening.
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