The authors describe a cylindrical retractor that is attached to a standard stereotaxic frame. This retractor provides a route for stereotaxic procedures and exposure of and a reference structure for the computer-assisted removal of deep-seated intracranial lesions defined stereotaxically by computerized tomography and magnetic resonance imaging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3171/jns.1988.69.2.0301 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative lipid profiling reveals the differential response of distinct lipid subclasses in blast and blunt-induced mild traumatic brain injury.
Exp Neurol
January 2025
Traumatic Brain Injury & Metabolomics Department, DRDO, Institute of Nuclear Medicine and Allied Sciences (INMAS), S. K Mazumdar Road, Timarpur, New Delhi 110054, India. Electronic address:
Head trauma from blast exposure is a growing health concern, particularly among active military personnel, and is considered the signature injury of the Gulf War. However, it remains elusive whether fundamental differences exist between blast-related traumatic brain injuries (TBI) and TBI due to other mechanisms. Considering the importance of lipid metabolism associated with neuronal membrane integrity and its compromise during TBI, we sought to find changes in lipidomic profiling during blast or blunt (Stereotaxically Controlled Contusison-SCC)-mediated TBI.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Background: Alzheimer's disease is a neurodegenerative disease associated with the accumulation of Amyloid-β and Tau neurofibrillary tangles following a pattern known as Thal and Braak stages, respectively (Thal 2002; Braak 1995,2011). Recent research (Pascoal 2020) showed the possibility of recapitulating Braak's histopathological stages in vivo using PET tracer [F]-MK-6240 with manually defined regions of interest. This study analyzes the joint patterns of Amyloid-β and Tau accumulation associated with AD in a completely data-driven fashion.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is characterized by the extracellular accumulation of senile plaques composed of beta-amyloid (Aβ) and the intracellular deposition of neurofibrillary tangles composed of hyperphosphorylated tau (Tp). Aβ induces a chronic neuroinflammation that contributes to the neurite network disorganization and finally neuronal death. Lecanemab, a humanized monoclonal antibody (Ab) that recognizes protofibrils/oligomers and prevents Aβ deposition, is the first US approved Ab for AD.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Background: Alzheimer's disease is a neurodegenerative disease associated with the accumulation of Amyloid-ß and Tau neurofibrillary tangles following a pattern known as Thal and Braak stages, respectively (Thal 2002; Braak 1995,2011). Recent research (Pascoal 2020) showed the possibility of recapitulating Braak's histopathological stages in vivo using PET tracer [18F]-MK-6240 with manually defined regions of interest. This study analyzes the joint patterns of Amyloid-ß and Tau accumulation associated with AD in a completely data-driven fashion.
View Article and Find Full Text PDFDrug Development.
Alzheimers Dement
December 2024
Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan, Iran (Islamic Republic of).
Background: Microbiota of the distal part of the intestine produces Urolithin A (Uro A) as a derivative of ellagitannins hydrolysis. Recently, the mitophagy, anti-inflammatory, and antioxidant properties of Uro A have focused more attention on its probable beneficial effects on neurodegenerative states. The purpose of this research was to study the impact of Uro A on the histopathology of the cerebellum in a rat model of streptozotocin-induced Alzheimer's disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!