Introduction: The novel coronavirus (COVID-19) pandemic has led to an increase in the number of patients presenting to the emergency department (ED) with severe hypoxia and acute respiratory distress. With limited resources and ventilators available, emergency physicians working at a hospital within the epicenter of the United States outbreak developed a stepwise, non-invasive oxygenation strategy for treating COVID-19 patients presenting with severe hypoxia and acute respiratory distress.
Case Report: A 72-year-old male suspected of having the COVID-19 virus presented to the ED with shortness of breath. He was found to be severely tachypneic, febrile, with rales in all lung fields. His initial oxygen saturation registered at SpO (blood oxygenation saturation) 55% on room air. Emergency physicians employed a novel non-invasive oxygenation strategy using a nasal cannula, non-rebreather, and self-proning. This approach led to a reversal of the patient's respiratroy distress and hypoxia (SpO2 88-95%) for the following 24 hours. This non-invasive intervention allowed providers time to obtain and initiate high-flow nasal cannula and discuss end-of-life wishes with the patient and his family.
Conclusion: Our case highlights a stepwise, organized approach to providing non-invasive oxygenation for COVID-19 patients presenting with severe hypoxia and acute respiratory distress. This approach primarily employs resources and equipment that are readily available to healthcare providers around the world. The intent of this strategy is to provide conventional alternatives to aid in the initial airway management of confirmed or suspected COVID-19 patients.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434237 | PMC |
http://dx.doi.org/10.5811/cpcem.2020.6.48456 | DOI Listing |
Introduction Chronic obstructive pulmonary disease (COPD) is a significant contributor to global morbidity and mortality. Despite well-established management protocols, treatment remains suboptimal due to high costs and mortality rates. This study aims to compare the impact of initial oxygenation status, Dyspnea, Eosinopenia, Consolidation, Acidemia, and Atrial Fibrillation (DECAF), and National Early Warning Score 2 (NEWS2) scores on management outcomes in COPD patients.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, the hypoxia and immunosuppressive tumor microenvironment (TME) often block the production of reactive oxygen species and the induction of SDT-activated immunogenic cell death, thus limiting the activation of adaptive immune responses. To alleviate these challenges, we proposed the development of a multifunctional biomimetic nanoplatform (mTSeIR), which was designed with diselenide-conjugated sonosensitizers and tirapazamine (TPZ), encapsulated within M1 macrophage membrane.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Cerebral metabolic rate of oxygen (CMRO) denotes the amount of O that the brain consumes. Changes in CMRO during aging and neurodegeneration have not been fully characterized. Using a non-invasive, non-contrast MRI CMRO technique, the present study reports CMRO changes in older adults from a total of 526 measurements, the largest CMRO dataset to date.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Translational Psychiatry Laboratory, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Background: Mild cognitive impairment(MCI) is characterized by an impairment in one or more cognitive domains greater than expected for a person's age and educational background with preserved functional independence. Functional Near Infra-Red Spectroscopy (fNIRS) is a modality of non-invasive neuroimaging that utilizes the optical properties of oxygenated and deoxygenated hemoglobin in the tissue to measure their absolute or relative concentrations following neuronal activity. fNIRS has been used to evaluate neurohemodynamics in MCI.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Cerebral metabolic rate of oxygen (CMRO2) denotes the amount of O2 that the brain consumes. Changes in CMRO2 during aging and neurodegeneration have not been fully characterized. Using a non-invasive, non-contrast MRI CMRO2 technique, the present study reports CMRO2 changes in older adults from a total of 526 measurements, the largest CMRO2 dataset to date.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!