Contrast-enhanced ultrasound-guided thrombin injection in the management of iatrogenic pseudoaneurysm (PSA): A case report and review of literatures.

Clin Hemorheol Microcirc

Interventional Ultrasound Unit, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Tongji University School of Medicine, Shanghai, China.

Published: February 2021

Pseudoaneurysm (PSA) formation is the most common arterial complication of endovascular procedures requiring arterial puncture. The present study reported a case of a 72-year-old male patient with iatrogenic femoral artery PSA treated with contrast-enhanced ultrasound (CEUS)-guided thrombin injection. Conventional ultrasound (US) and CEUS were used to diagnose, guide treatment, and evaluate the treatment efficacy. In the case, the PSA was successfully occluded with 1000 IU of thrombin. During the follow-up after 48 hours of thrombin injection, US found that the PSA had complete thrombosis without arterial supply. No complications occurrence in the course of the treatment. CEUS-guided thrombin injection for the treatment of PSA was effective and safety and the associated literatures were also reviewed.

Download full-text PDF

Source
http://dx.doi.org/10.3233/CH-200923DOI Listing

Publication Analysis

Top Keywords

thrombin injection
16
pseudoaneurysm psa
8
ceus-guided thrombin
8
psa
6
thrombin
5
contrast-enhanced ultrasound-guided
4
ultrasound-guided thrombin
4
injection
4
injection management
4
management iatrogenic
4

Similar Publications

Objective: To investigate the safety and effectiveness of balloon occlusion and intra-sac thrombin injection in the endovascular repair of ruptured abdominal aortic aneurysm.

Methods: From October 2019 to October 2022, the clinical data of 16 patients with rAAA treated with balloon occlusion technique and intra-sac thrombin injection combined with EVAR were retrospectively analyzed, including 13 males and 3 females, aged 42-85 years, with a median age of 70.5 years.

View Article and Find Full Text PDF

Pseudoaneurysms develop as a result of disruption of the arterial wall due to trauma or iatrogenic reasons such as catheterization, and it is important due to the high risk of bleeding and rupture. Until recently, the main treatment of pseudoaneurysms was surgical repair. However, in recent years, minimally invasive methods such as ultrasound-guided compression and percutaneous thrombin injection have been used more frequently.

View Article and Find Full Text PDF

Bidirectional Enzyme Inhibition and Activation for In Situ Formation of Injectable Hydrogel Using a Bispecific Aptamer.

Langmuir

December 2024

Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Article Synopsis
  • - The study focuses on in situ injectable hydrogels, which are important for applications in regenerative medicine and drug delivery, but face challenges in controlling gelation speed for easier injection.
  • - Researchers investigated a system using bispecific aptamers that can inhibit thrombin (an enzyme involved in clotting) to slow down the formation of fibrin hydrogels.
  • - The study found that when these aptamers interacted with complementary sequences, they could reverse the inhibition, speeding up the hydrogel formation process, demonstrating a new dynamic control for enzyme-mediated hydrogel development.
View Article and Find Full Text PDF
Article Synopsis
  • Isorhynchophylline, a Chinese herbal medicine, shows anti-inflammatory and neuroprotective effects, but its impact on platelet function was previously unknown.
  • The study found that isorhynchophylline reduces platelet aggregation and activation in a dose-dependent manner and does not affect surface levels of key receptors.
  • In vivo tests on mice indicated that isorhynchophylline impairs hemostatic function and thrombus formation, suggesting it might be useful for treating thrombotic and cardiovascular diseases.
View Article and Find Full Text PDF
Article Synopsis
  • * Symptoms and characteristics of PSAs can vary, making diagnosis important, which can be done using ultrasonography, CT scans, or other imaging techniques.
  • * Treatment options for PSAs include surgical methods, ultrasound-guided therapies, and advanced endovascular techniques, along with a discussion of risk factors and potential complications.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!